Acetylcysteamine → 7-(2-acetamidoethylthio)-N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

関与物質

反応条件

反応手順

N-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-fluoroimidazo[1,2-a]pyridine-3-carboxamide (0.028 g, 0.065 mmol) (Example 74, Step A), N-(2-mercaptoethyl)acetamide (0.078 g, 0.65 mmol), and potassium tert-butoxide (0.022 g, 0.20 mmol) were added to a minimal amount of deoxygenated 1,4-dioxane in a sealed tube and heated for 18 hours at 95° C. The reaction mixture was cooled, concentrated under reduced pressure and purified by silica gel chromatography eluting with methanol (containing 6% ammonium hydroxide) and dichloromethane (1:9), to yield the product (20 mg) as a white powder. MS ESI (+) m/z 528 (M+1) detected.

情報源と証拠