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1,2-Dimethoxyethane → 7-Azaindole N-oxide 3-chlorobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 反応物 | 1H-Pyrrolo(2,3-b)pyridine | HCID 9222 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 生成物 | 7-Azaindole N-oxide 3-chlorobenzoate | HCID 11572863 | 89.4% |
反応手順
meta-Chloroperbenzoic acid (“m-CPBA”; 25.4 g, 147 mmol) was added portionwise to 1H-pyrrolo[2,3-b]pyridine (15.0 g, 127 mmol) in 1:2 dimethoxyethane (“DME”):heptane (80:160 mL) at 10° C. The reaction was then stirred at room temperature for 1 hour. The precipitate was filtered and washed with 1:2 DME:heptane. The precipitate was then dried to give 7-hydroxy-1H-pyrrolo[2,3-b]pyridin-7-ium 3-chlorobenzoate (33.0 g, 89.4% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841304B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-3ad0b0570cd948589fc657a1adacabd3 |
| 出典メモ | uspto-grants-2014_09 |