2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 2-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 7983ノート

反応式

HRID 7983 の反応式
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:58])[N:37]([CH2:49][CH:50]=[CH:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=2)[CH:40]=1)(O)=[O:33]>>[CH2:49]([N:37]1[C:36](=[O:58])[C:35]([CH2:32][OH:33])=[CH:40][C:39]([C:41]2[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=2)=[N:38]1)[CH:50]=[CH:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1

参加物

3

反応物 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 672133534-carboxy-2-cinnamyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

生成物 1

HCID 672133632-cinnamyl-6-(4-fluoro-3-methylphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

実験手順

Following the procedure of Example 1 (8), 4-carboxy-2-cinnamyl-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 20.1%).

後処理

  1. customwas reacted

出典と根拠

ORDレコード
ord-535ad6d41210447d8a3bfdad5a29b12b
出典データセット
uspto-grants-2006_08
特許番号
US07087606B2

反応ノート

読み込み中…