2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester → 4-Difluoromethoxy-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

HRID 79899

反応式

HRID 79899 の反応式
C(OC(N1CC(O[CH:14]([F:16])[F:15])CC1C1NC(C2C=CC(Br)=CC=2)=CN=1)=O)(C)(C)C.C(OC(N1CC(O)CC1C1NC(C2C=CC(Br)=CC=2)=CN=1)=O)(C)(C)C.[C:54]([O:58][C:59]([N:61]1[CH2:65][CH:64]([OH:66])[CH2:63][CH:62]1[C:67]([O:69][CH2:70][C:71]([C:73]1[CH:78]=[CH:77][C:76]([Br:79])=[CH:75][CH:74]=1)=[O:72])=[O:68])=[O:60])([CH3:57])([CH3:56])[CH3:55]>>[C:54]([O:58][C:59]([N:61]1[CH2:65][CH:64]([O:66][CH:14]([F:16])[F:15])[CH2:63][CH:62]1[C:67]([O:69][CH2:70][C:71]([C:73]1[CH:78]=[CH:77][C:76]([Br:79])=[CH:75][CH:74]=1)=[O:72])=[O:68])=[O:60])([CH3:57])([CH3:55])[CH3:56]

参加物

4

反応物 3

HCID 666203882-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl esterHCID 666209004-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl esterHCID 723381365-(4-Bromo-phenyl)-1H-imidazol-2-yl-4-difluoromethoxy-pyrrolidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 666212034-Difluoromethoxy-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester

実験手順

2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl-4-difluoromethoxy-pyrrolidine-1-carboxylic acid tert-butyl ester: Title compound was prepared according to the method employed to prepare 2-[5-(4-Bromo-phenyl)-1H-imidazol-2-yl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (Example 1), substituting 4-Difluoromethoxy-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (305 mg) for 4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 2-[2-(4-bromo-phenyl)-2-oxo-ethyl]ester 1-tert-butyl ester (244 mg, 83%).

出典と根拠

ORDレコード
ord-1789618bb94b47d28ca12c8181e881b6
出典データセット
uspto-grants-2014_09
特許番号
US08841278B2

関連ノート

読み込み中…