2-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazine → 2-Methoxycarbonylamino-4-(2,2,2-trifluoro-ethoxy)-butyric acid methyl ester

HRID 79965ノート

反応式

HRID 79965 の反応式
[CH3:1][O:2][C:3](=[O:16])[CH:4]([NH:11][C:12]([O:14][CH3:15])=[O:13])[CH2:5][CH2:6]C(F)(F)F.C(C1C(OC)=NC(CC[O:30][CH2:31][C:32]([F:35])([F:34])[F:33])C(OC)=N1)(C)C>>[CH3:1][O:2][C:3](=[O:16])[CH:4]([NH:11][C:12]([O:14][CH3:15])=[O:13])[CH2:5][CH2:6][O:30][CH2:31][C:32]([F:35])([F:34])[F:33]

参加物

3

反応物 2

HCID 666204602-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazineHCID 723378835,5,5-Trifluoro-2-methoxycarbonylamino-pentanoic acid methyl ester

生成物 1

HCID 723380202-Methoxycarbonylamino-4-(2,2,2-trifluoro-ethoxy)-butyric acid methyl ester

実験手順

This compound was made by the same procedure as 5,5,5-Trifluoro-2-methoxycarbonylamino-pentanoic acid methyl ester, using 2-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazine as the starting material. 1H-NMR: 400 MHz, (CDCl3) δ: 5.51-5.43 (br, 1H), 4.51-4.43 (m, 1H), 3.83-3.63 (m, 10H), 2.22-2.13 (m, 1H), 2.13-2.03 (m, 1H) ppm.

出典と根拠

ORDレコード
ord-05a61e19bfd14566a1b09c363a900788
出典データセット
uspto-grants-2014_09
特許番号
US08841278B2

反応ノート

読み込み中…