Dimethylamine → HCID 21991546、化合物

HRID 7999ノート

反応式

HRID 7999 の反応式
C(OC(N1C[CH2:12][N:11]([C:14]2[C:15](=[O:33])[N:16]([CH2:29][CH:30]([CH3:32])[CH3:31])[N:17]=[C:18]([C:21]3[CH:26]=[CH:25][C:24](C)=[C:23](F)[CH:22]=3)[C:19]=2[CH3:20])[CH2:10]C1)=O)(C)(C)C.C1(CN2C(=O)C(C[O:46][S:47]([CH3:50])(=O)=[O:48])=CC(C3C=CC(S(C)(=O)=O)=CC=3)=N2)CC1.CNC>>[CH:30]1([CH2:29][N:16]2[C:15](=[O:33])[C:14]([N:11]([CH3:10])[CH3:12])=[C:19]([CH3:20])[C:18]([C:21]3[CH:22]=[CH:23][C:24]([S:47]([CH3:50])(=[O:48])=[O:46])=[CH:25][CH:26]=3)=[N:17]2)[CH2:31][CH2:32]1

参加物

4

反応物 3

HCID 674DimethylamineHCID 219916462-cyclopropylmethyl-4-methanesulfonyloxymethyl-6-[4-(methyl-sulfonyl)phenyl]-2H-pyridazin-3-oneHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one

生成物 1

HCID 21991546HCID 21991546、化合物収率 65.6%

実験手順

Following the procedure of Example 1 (10), 2-cyclopropylmethyl-4-methanesulfonyloxymethyl-6-[4-(methyl-sulfonyl)phenyl]-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow oil (yield: 65.6%).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-51117be8824c445abd4949fe380f7aba
出典データセット
uspto-grants-2006_08
特許番号
US07087606B2

反応ノート

読み込み中…