化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → 1-(2-Chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 反応物 | 3-Amino-4-picoline | HCID 137935 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-(2-Chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea | HCID 14834325 | 86.1% |
反応手順
1-Chloro-2-isocyanato-ethane (5.91 ml, 69.35 mmol) was added dropwise to a stirred solution of 4-methyl-pyridin-3-ylamine (5 g, 46.23 mmol) in toluene (180 mL) at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 8.5 g (86% yield) of 1-(2-chloro-ethyl)-3-(4-methyl-pyridin-3-yl)-urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045173E1 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-30b9272dcda744cebc823dc473c6935a |
| 出典メモ | uspto-grants-2014_09 |