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Methanol → Urea, 1-(2-chloroethyl)-3-(2-naphthyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 2-Naphthylamine | HCID 7057 | — |
| 反応物 | 2-Chloroethyl isocyanate | HCID 16035 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Urea, 1-(2-chloroethyl)-3-(2-naphthyl)- | HCID 256650 | 83.2% |
反応手順
1-Chloro-2-isocyanato-ethane (0.81 mL, 9.42 mmol) was added dropwise to a stirred solution of naphthalen-2-ylamine (900 mg, 6.28 mmol) in toluene (50 mL) over a period of 30 minutes at 0° C. The reaction temperature was maintained at room temperature for 5 hours. The reaction was monitored by TLC (5% MeOH in chloroform). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 1.3 g (83% yield) of 1-(2-chloro-ethyl)-3-naphthalen-2-yl-urea.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045173E1 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-7d1e7ba22c45424894f9727198bc3033 |
| 出典メモ | uspto-grants-2014_09 |