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Methanesulfonate → 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | 3-(4-Fluorophenyl)propan-1-ol | HCID 13747241 | — |
| 反応物 | 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991432 | — |
| 反応物 | 6-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one | HCID 21991662 | — |
| 生成物 | 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one | HCID 21991461 | 90.1% |
反応手順
Following the procedure of Example 1 (6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and the mesylate derivative of 3-(4-fluorophenyl)-1-propanol {J. Med. Chem., 19, 461 (1976)} were reacted to yield the title compound as a yellow oil (yield: 90.1%). The mesylate derivative was prepared in accordance with the procedure of Example 1 (9).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087606B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-9757eb78aaf243dd8b7402bab0cddbc6 |
| 出典メモ | uspto-grants-2006_08 |