Ethyl Acetate → 1-(3-Chloro-propyl)-3-(4-methyl-pyridin-3-yl)-urea
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][N:5]=[C:6]=[O:7].[CH3:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[NH2:15].C(OC(=O)C)C>C1(C)C=CC=CC=1>[Cl:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]([NH:15][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][C:9]=1[CH3:8])=[O:7]参加物
5
実験手順
1-Chloro-3-isocyanato-propane (1.6 g, 13.87 mmol) was added dropwise to a stirred solution of 4-methyl-pyridin-3-ylamine (1 g, 9.25 mmol) in toluene (15 mL) at 0° C. The reaction mixture was stirred at room temperature for 18 hours. The reaction was monitored by TLC (100% ethylacetate). The reaction mixture was filtered, washed with toluene and dried under reduced pressure to afford 2.12 g (99.5% yield) of 1-(3-chloro-propyl)-3-(4-methyl-pyridin-3-yl)-urea.
後処理
- filtrationThe reaction mixture was filtered
- washwashed with toluene
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-9a0901e38543443595773620a15309ea
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- USRE045173E1
反応ノート
読み込み中…