Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one
反応式
C([O-])(=O)C.[Na+].Br[CH2:7][C:8](=[O:11])[CH2:9][CH3:10].[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1.C(OCC)(=O)C>CO.CCCCCC>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][CH2:7][C:8](=[O:11])[CH2:9][CH3:10])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1参加物
7
実験手順
Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).
後処理
- customThe resulting reaction mass
- filtrationThe reaction mixture was filtered
- customthe solid collected
- customwas dried under reduced pressure
出典と根拠
- ORDレコード
- ord-71203114ad6d41cfaacd277bb5ec8620
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- USRE045173E1
反応ノート
読み込み中…