Ethyl Acetate → 1-(Benzothiazol-6-ylamino)-butan-2-one

HRID 80221

反応式

HRID 80221 の反応式
C([O-])(=O)C.[Na+].Br[CH2:7][C:8](=[O:11])[CH2:9][CH3:10].[S:12]1[C:16]2[CH:17]=[C:18]([NH2:21])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1.C(OCC)(=O)C>CO.CCCCCC>[S:12]1[C:16]2[CH:17]=[C:18]([NH:21][CH2:7][C:8](=[O:11])[CH2:9][CH3:10])[CH:19]=[CH:20][C:15]=2[N:14]=[CH:13]1

参加物

7

反応物 4

HCID 8857Ethyl AcetateHCID 131561-Bromo-2-butanoneHCID 682886-AminobenzothiazoleHCID 517045Sodium Acetate

生成物 1

HCID 596361951-(Benzothiazol-6-ylamino)-butan-2-one収率 34.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8058Hexane溶媒

実験手順

Sodium acetate (300 mg, 3.66 mmol) and 1-bromo-butan-2-one (0.373 mL, 3.66 mmol) were added to a stirred solution of benzothiazol-6-ylamine (500 mg, 3.328 mmol) in methanol (10 mL) under nitrogen atmosphere. The resulting reaction mass was stirred at room temperature for 24 hours. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered and the solid collected was dried under reduced pressure to afford 250 mg of the product (32% yield).

後処理

  1. customThe resulting reaction mass
  2. filtrationThe reaction mixture was filtered
  3. customthe solid collected
  4. customwas dried under reduced pressure

出典と根拠

ORDレコード
ord-71203114ad6d41cfaacd277bb5ec8620
出典データセット
uspto-grants-2014_09
特許番号
USRE045173E1

関連ノート

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