反応式
[S:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:11][C:12]([F:19])([F:18])[C:13](=[CH2:17])[C:14]([OH:16])=[O:15].C1(O)C=CC(O)=CC=1>C1(C)C=CC=CC=1>[S:1]1[C:5]2[CH:6]=[C:7]([NH:10][CH2:17][CH:13]([C:12]([F:19])([F:18])[F:11])[C:14]([OH:16])=[O:15])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1参加物
5
実験手順
Benzothiazol-6-ylamine (1 g, 6.66 mmol) was reacted with 2-trifluoromethyl-acrylic acid (1.39 g, 9.99 mmol), benzene-1,4-diol (51.3 mg, 0.46 mmol) and toluene (10 mL) to afford the crude product. Purification by column chromatography on silica gel (30% ethyl acetate in hexane) afforded 380 mg of the product (19.67% yield).
後処理
- customto afford the crude product
- customPurification by column chromatography on silica gel (30% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-6d1d424c5a7a4c2f8b46c6ddd81528a5
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- USRE045173E1
関連ノート
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