Methanol → HCID 178517345、化合物

HRID 80245ノート

反応式

HRID 80245 の反応式
Cl.O1CCOCC1.[S:8]1[C:12]2[CH:13]=[C:14]([N:17]3[CH2:21][CH2:20][N:19]([C:22]4[CH:23]=[C:24]5[N:30]=[CH:29][N:28](OCC[Si](C)(C)C)[C:25]5=[N:26][CH:27]=4)[C:18]3=[O:38])[CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1.CO>C(Cl)Cl>[S:8]1[C:12]2[CH:13]=[C:14]([N:17]3[CH2:21][CH2:20][N:19]([C:22]4[CH:23]=[C:24]5[N:30]=[CH:29][NH:28][C:25]5=[N:26][CH:27]=4)[C:18]3=[O:38])[CH:15]=[CH:16][C:11]=2[N:10]=[CH:9]1

参加物

5

反応物 3

HCID 887MethanolHCID 204431481,4-Dioxane hydrochlorideHCID 596362291-benzothiazol-6-yl-3-[3-(2-trimethylsilanyl-ethoxy)-3H-imidazo[4,5-b]pyridin-6-yl]-imidazolidin-2-one

生成物 1

HCID 178517345HCID 178517345、化合物収率 27.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1,4-Dioxane HCl (5 ml) was added to 1-benzothiazol-6-yl-3-[3-(2-trimethylsilanyl-ethoxy)-3H-imidazo[4,5-b]pyridin-6-yl]-imidazolidin-2-one (I-183b: 100 mg, 0.2145 mmol) and the resulting mixture was stirred room temperature for 6 hours. The reaction was monitored by TLC (10% MeOH in DCM). The reaction mixture was concentrated and washed with diethyl ether. Purification by preparative HPLC afforded 20 mg of the product (25.4% yield).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. washwashed with diethyl ether
  3. customPurification by preparative HPLC

出典と根拠

ORDレコード
ord-8f9985ba741d4e2ab9d16ba8b0551b8c
出典データセット
uspto-grants-2014_09
特許番号
USRE045173E1

反応ノート

読み込み中…