化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl Acetate → 3-Chloro-2,2-dimethyl-propionyl azide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 3-Chloro-2,2-dimethylpropanoyl chloride | HCID 61345 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 3-Chloro-2,2-dimethyl-propionyl azide | HCID 59636160 | 61.4% |
反応手順
Sodium azide (4.64 g, 71.38 mmol) was added to a solution of 3-chloro-2,2-dimethyl-propionyl chloride (I-200a: 6 g, 35.71 mmol) in 1,4-dioxane (15 mL) and water (15 mL). The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (5% ethylacetate in hexane). The reaction mixture was extracted with diethyl ether and the organic layer was dried over Na2SO4 to afford 3.5 g of the product (61.40% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045173E1 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-61aeecbee34f43d2baa40b2c427cbaf5 |
| 出典メモ | uspto-grants-2014_09 |