6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 4-carboxy-2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

HRID 8029ノート

反応式

HRID 8029 の反応式
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[F:26][C:27]1[CH:28]=[C:29]([CH:51]=[CH:52][C:53]=1[F:54])[CH2:30][N:31]1[C:36](=[O:37])[C:35]([C:38]([O:40]C)=[O:39])=[CH:34][C:33]([C:42]2[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[C:44]([F:50])[CH:43]=2)=[N:32]1>>[C:38]([C:35]1[C:36](=[O:37])[N:31]([CH2:30][C:29]2[CH:51]=[CH:52][C:53]([F:54])=[C:27]([F:26])[CH:28]=2)[N:32]=[C:33]([C:42]2[CH:47]=[CH:46][C:45]([O:48][CH3:49])=[C:44]([F:50])[CH:43]=2)[CH:34]=1)([OH:40])=[O:39]

参加物

3

反応物 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 219916662-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

生成物 1

HCID 219914784-carboxy-2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one収率 97.6%

実験手順

Following the procedure of Example 1 (7), 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow crystalline powder (yield: 97.6%).

後処理

  1. customwas reacted

出典と根拠

ORDレコード
ord-fd0da7479f3c4910bc9f48780c1874b2
出典データセット
uspto-grants-2006_08
特許番号
US07087606B2

反応ノート

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