Hydrochloric Acid → 2-(Ethoxycarbonyl)butanoic acid

Diethyl ethylmalonate was stirred overnight with 95% ethanol in the presence of 1M KOH. The white precipitate that forms was filtered out of solution, and the filtrate was concentrated under reduced pressure (e.g., on a rotary evaporator). The yellowish oil obtained upon concentration of the filtrate was added to the precipitate and the mixture was dissolved in a minimum amount of water. After acidification with dilute aqueous HCl to a pH of 2, an oil separates from the solution. The oil was taken up into diethyl ether and the aqueous layer was extracted three times with further with diethyl ether. The ether extracts were combined, dried over magnesium sulfate and filtered. A quantitative yield of 2-carboethoxybutyric acid was obtained as a yellowish oil.

1. filtrationThe white precipitate that forms was filtered out of solution
2. concentrationthe filtrate was concentrated under reduced pressure (e.g.
3. customon a rotary evaporator)
4. customThe yellowish oil obtained upon concentration of the filtrate
5. additionwas added to the precipitate
6. extractionthe aqueous layer was extracted three times with further with diethyl ether
7. dry with materialdried over magnesium sulfate
8. filtrationfiltered

ORDレコード

ord-5eb28bacb9664f2fa52b58188a0537d2

出典データセット

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08846021B2