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3-(Trifluoromethyl)phenol → 4-Bromo-2-methylthio-6-[3-(trifluoromethyl)phenoxy]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4,6-Dibromo-2-(methylthio)pyrimidine | HCID 15003622 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-Bromo-2-methylthio-6-[3-(trifluoromethyl)phenoxy]pyrimidine | HCID 19693894 | — |
反応手順
In THF, a phenoxide was prepared from m-(trifluoromethyl)phenol (1.30 g, 0.00794×1.0 mol) and NaH (0.32 g (ca. 60% in mineral oil), 0.00794×1.0 mol), and 4,6-dibromo-2-(methylthio)pyrimidine (Compound No. VII-22) (2.0 g, 0.00794 mol) was added thereto, and the mixture was then allowed to react for 5 hours at room temperature.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723412 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3df2c010cc0541928156900e8959ed27 |
| 出典メモ | uspto-grants-1998_03 |