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3,4,5-Trimethoxybenzeneboronic acid → 4-[5-(3,4,5-Trimethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4,5-Trimethoxybenzeneboronic acid | HCID 2734390 | — |
| 反応物 | 4-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane | HCID 86649249 | — |
| 生成物 | 4-[5-(3,4,5-Trimethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane | HCID 49869428 | — |
反応手順
The title compound was prepared from the product of Example 65A and 3,4,5-trimethoxyphenylboronic acid according to General Method B: 1H NMR (500 MHz, CDCl3) δ ppm 8.16 (s, 2 H), 7.03 (s, 1 H), 6.73 (s, 2 H), 4.1 (s, 1 H), 3.91 (s, 9H.), 3.73-3.37 (m, 5 H), 3.05-3.00 (m, 4 H), 2.27-2.17 (m, 5 H); LC-MS Method D (ESI+) m/z 396.0 (M+H)+, retention time 1.32 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846661B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-f996ed83be284815b88e75745fb937f5 |
| 出典メモ | uspto-grants-2014_09 |