3,4-Dimethoxyphenylboronic acid → 4-[5-(3,4-Dimethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80436

反応式

HRID 80436 の反応式
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23](B(O)O)[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]>>[CH3:19][O:20][C:21]1[CH:22]=[C:23]([C:2]2[CH:3]=[C:4]([N:8]3[CH2:16][CH:15]4[CH2:17][N:11]5[CH2:12][CH:13]([CH2:18][CH:9]3[CH2:10]5)[CH2:14]4)[CH:5]=[N:6][CH:7]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH3:28]

参加物

3

反応物 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

生成物 1

HCID 498697124-[5-(3,4-Dimethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

実験手順

The title compound was prepared from the product of Example 65A and 3,4-dimethoxyphenylboronic acid according to General Method B: 1H NMR (500 MHz, CDCl3) δ ppm 8.14 (d, 2 H), 7.19 (d, 1 H), 7.07 (d, 2 H), 6.93 (d, 1 H), 4.13 (s, 1 H), 3.91 (s, 3 H), 3.87 (s, 3 H), 3.81-3.30 (m, 7 H), 3.09-2.95 (m, 4 H), 2.34-2.18 (m, 3 H); LC-MS Method D (ESI+) m/z 366.0 (M+H)+, retention time 1.28 minutes.

出典と根拠

ORDレコード
ord-34352c502dcd48a9a5f9f9aad989801d
出典データセット
uspto-grants-2014_09
特許番号
US08846661B2

関連ノート

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