(3-Acetamidophenyl)boronic acid → N-{3-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}acetamide

HRID 80448

反応式

HRID 80448 の反応式
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[C:19]([NH:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1)(=[O:21])[CH3:20]>>[N:11]12[CH2:17][CH:15]3[CH2:14][CH:13]([CH2:18][CH:9]([N:8]([C:4]4[CH:3]=[C:2]([C:27]5[CH:28]=[C:23]([NH:22][C:19](=[O:21])[CH3:20])[CH:24]=[CH:25][CH:26]=5)[CH:7]=[N:6][CH:5]=4)[CH2:16]3)[CH2:10]1)[CH2:12]2

参加物

3

反応物 2

HCID 157274(3-Acetamidophenyl)boronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

生成物 1

HCID 68785017N-{3-[5-(1,4-diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]phenyl}acetamide

実験手順

The title compound was prepared from the product of Example 65A and 3-acetamidophenylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 363.0 (M+H)+, retention time 1.21 minutes.

出典と根拠

ORDレコード
ord-8c8be81a0e8644059a2d82a2dd2e0c10
出典データセット
uspto-grants-2014_09
特許番号
US08846661B2

関連ノート

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