(6-Methoxypyridin-3-yl)boronic acid → 4-(6'-Methoxy-3,3'-bipyridin-5-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

反応式

Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[CH3:19][O:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][N:22]=1>>[CH3:19][O:20][C:21]1[N:22]=[CH:23][C:24]([C:2]2[CH:7]=[N:6][CH:5]=[C:4]([N:8]3[CH2:16][CH:15]4[CH2:17][N:11]5[CH2:12][CH:13]([CH2:18][CH:9]3[CH2:10]5)[CH2:14]4)[CH:3]=2)=[CH:25][CH:26]=1

参加物

反応物 2

HCID 2734368(6-Methoxypyridin-3-yl)boronic acid

HCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

生成物 1

HCID 866492594-(6'-Methoxy-3,3'-bipyridin-5-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

実験手順

The title compound was prepared from the product of Example 65A and 2-methoxypyridin-5-ylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 337.0 (M+H)+, retention time 1.23 minutes.

出典と根拠

ORDレコード: ord-d1dadbd5521b40489220371ffe138f18
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846661B2

反応ノート

読み込み中…