(5-Acetylthiophen-2-yl)boronic acid → 1-{5-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]thien-2-yl}ethanone

HRID 80451

反応式

HRID 80451 の反応式
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[C:19]([C:22]1[S:26][C:25](B(O)O)=[CH:24][CH:23]=1)(=[O:21])[CH3:20]>>[N:11]12[CH2:17][CH:15]3[CH2:14][CH:13]([CH2:18][CH:9]([N:8]([C:4]4[CH:3]=[C:2]([C:25]5[S:26][C:22]([C:19](=[O:21])[CH3:20])=[CH:23][CH:24]=5)[CH:7]=[N:6][CH:5]=4)[CH2:16]3)[CH2:10]1)[CH2:12]2

参加物

3

反応物 2

HCID 4143377(5-Acetylthiophen-2-yl)boronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

生成物 1

HCID 498697151-{5-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]thien-2-yl}ethanone

実験手順

The title compound was prepared from the product of Example 65A and 5-acetylthiophen-2-ylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 354.0 (M+H)+, retention time 1.26 minutes.

出典と根拠

ORDレコード
ord-917fa7097abf466f9640519bf4ee2b13
出典データセット
uspto-grants-2014_09
特許番号
US08846661B2

関連ノート

読み込み中…