Tolylboronic acid → 4-[5-(4-Methylphenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

反応式

Br[C:2]1[S:6][C:5]([N:7]2[CH2:15][CH:14]3[CH2:16][N:10]4[CH2:11][CH:12]([CH2:17][CH:8]2[CH2:9]4)[CH2:13]3)=[N:4][CH:3]=1.[CH3:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[S:6][C:5]([N:7]3[CH2:15][CH:14]4[CH2:16][N:10]5[CH2:11][CH:12]([CH2:17][CH:8]3[CH2:9]5)[CH2:13]4)=[N:4][CH:3]=2)=[CH:21][CH:20]=1

参加物

反応物 2

HCID 79799Tolylboronic acid

HCID 866492624-(5-Bromo-1,3-thiazol-2-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

生成物 1

HCID 866492634-[5-(4-Methylphenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

実験手順

The title compound was prepared from the product of Example 105A and 4-methylphenylboronic acid according to General Method C: LC-MS Method D (ESI+) m/z 326.0 (M+H)+, retention time 1.54 minutes.

出典と根拠

ORDレコード: ord-ea4f8710fcd445aaa0035d392d882edf
出典データセット: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08846661B2

反応ノート

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