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Potassium Carbonate → 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(Diethylamino)-1-propanol | HCID 12159 | — |
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | 3-Fluoro-4-nitrophenol | HCID 520948 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene | HCID 22014733 | — |
反応手順
A solution of 3-fluoro-4-nitrophenol (2 mmol) and methanesulfonate of 3-diethylamino-1-propanol (2.5 mmol) in DMF (4 mL) is added with K2CO3 (4 mmol) and heated following the general procedure III (Step A). The product, 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene is obtained (470 mg) after purification using silica gel column chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087632B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-f375c00562a24af688c5e95063e27f6d |
| 出典メモ | uspto-grants-2006_08 |