Ethyl Acetate → 2-Nitro-5-(3-diethylamino-1-propoxy)aniline

HRID 8050

反応式

HRID 8050 の反応式
F[C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])[CH:5]=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].C(=O)([O-])[O-].[NH4+:24].[NH4+].CCOC(C)=O>CN(C=O)C>[N+:17]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][N:12]([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:7][C:2]=1[NH2:24])([O-:19])=[O:18]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 517111Ammonium CarbonateHCID 220147332-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene

生成物 1

HCID 220147182-Nitro-5-(3-diethylamino-1-propoxy)aniline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.

後処理

  1. washThe combined organic layers are then washed with water and brine
  2. dry with materialdried over Na2SO4
  3. customRemoval of the solvent in vacuo

出典と根拠

ORDレコード
ord-2376017b04d24493a40d98ac5b74b779
出典データセット
uspto-grants-2006_08
特許番号
US07087632B2

関連ノート

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