Benzenemethanamine, 2,5-dichloro- → 7-Bromo-1-(2,5-dichlorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine

HRID 80545

反応式

HRID 80545 の反応式
[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.Cl[C:11]1C(F)=CC=C(F)[C:12]=1CN.[Cl:21][C:22]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:23]=1[CH2:24][NH2:25]>>[Br:9][C:5]1[N:6]=[C:7]2[N:25]([CH2:24][C:23]3[CH:26]=[C:27]([Cl:30])[CH:28]=[CH:29][C:22]=3[Cl:21])[CH2:11][CH2:12][NH:1][C:2]2=[N:3][CH:4]=1

参加物

4

反応物 3

HCID 457600Benzenemethanamine, 2,5-dichloro-HCID 6200042-Amino-3,5-dibromopyrazineHCID 27735452-Chloro-3,6-difluorobenzylamine

生成物 1

HCID 866594237-Bromo-1-(2,5-dichlorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine

実験手順

7-bromo-1-(2,5-dichlorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine was prepared from 2-amino-3,5-dibromopyrazine as described in Example 1 by replacing 2-chloro-3,6-difluorobenzylamine in step 1 with 2,5-dichlorobenzylamine.

出典と根拠

ORDレコード
ord-ff3915d97c9c45dca268b0d902de2bfe
出典データセット
uspto-grants-2014_09
特許番号
US08846664B2

関連ノート

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