2-Amino-3,5-dibromopyrazine → 7-Bromo-1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine

HRID 80555

反応式

HRID 80555 の反応式
[NH2:1][C:2]1[C:7](Br)=[N:6][C:5]([Br:9])=[CH:4][N:3]=1.Cl[C:11]1C(F)=CC=C(F)[C:12]=1CN.[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:30]([F:33])([F:32])[F:31])=[C:26]([CH:29]=1)[CH2:27][NH2:28]>>[Br:9][C:5]1[N:6]=[C:7]2[N:28]([CH2:27][C:26]3[CH:29]=[C:22]([Cl:21])[CH:23]=[CH:24][C:25]=3[C:30]([F:31])([F:32])[F:33])[CH2:11][CH2:12][NH:1][C:2]2=[N:3][CH:4]=1

参加物

4

反応物 3

HCID 6200042-Amino-3,5-dibromopyrazineHCID 27735452-Chloro-3,6-difluorobenzylamineHCID 201117085-Chloro-2-(trifluoromethyl)benzylamine

生成物 1

HCID 866594267-Bromo-1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine

実験手順

7-bromo-1-[5-chloro-2-(trifluoromethyl)benzyl]-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine was prepared as described in Example 1 from 2-amino-3,5-dibromopyrazine as described in Example 1 by replacing 2-chloro-3,6-difluorobenzylamine in step 1 with 5-chloro-2-trifluoromethyl-benzylamine.

出典と根拠

ORDレコード
ord-1ecf8e89ab0a4af795315346b97f8ac6
出典データセット
uspto-grants-2014_09
特許番号
US08846664B2

関連ノート

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