化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → ethyl 3,5-dimethyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | (4-Methylphenyl)hydrazine | HCID 10875 | — |
| 反応物 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | ethyl 3,5-dimethyl-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate | HCID 2766289 | — |
反応手順
Similar to Example 1, p-tolylhydrazine (10 mmol, 1.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a solution of 50% pyridine in ethanol. The solvents were removed under vacuum. The named product was purified over silica gel (m.p. 47° C.–49° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087634B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-8a2a370daa1e478a88c3bf3e9f78a9ca |
| 出典メモ | uspto-grants-2006_08 |