関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine | HCID 4184869 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,1-Dimethylethyl 4-azido-1-piperidinecarboxylate | HCID 11458794 | — |
反応手順
A mixture of 4-methanesulfonyloxy-piperidine-1-carboxylic acid tert-butyl ester and sodium azide in DMF was stirred at 60° C. overnight. The mixture was poured into water and the resulting mixture was extracted with EtOAc. The organic phase was separated and washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo to give the desired product as a pale yellow oil, which was used without further purification. 1H NMR (CDCl3): δ 7.9 (2H, d), 7.12 (2H, d), 4.79 (2H, d), 3.05 (3H, s), 2.58 9 (1H, t).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846675B2 |
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| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ce68c2a1ab834a2e9cd0d8d7b7513280 |
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| 出典メモ | uspto-grants-2014_09 |
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