1-Butanesulfonyl chloride → 5-((2-(1-(Butylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine

HRID 80659

反応式

HRID 80659 の反応式
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:4][CH2:3]1.[CH2:26]([S:30](Cl)(=[O:32])=[O:31])[CH2:27][CH2:28][CH3:29]>>[CH2:26]([S:30]([N:2]1[CH2:3][CH2:4][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:6][CH2:7]1)(=[O:32])=[O:31])[CH2:27][CH2:28][CH3:29]

参加物

3

反応物 2

HCID 754301-Butanesulfonyl chlorideHCID 687466245-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride

生成物 1

HCID 251744265-((2-(1-(Butylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine

実験手順

The title compound was synthesized using Intermediate 15 and 1-butanesulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 10.08 (1H, s), 8.41 (1H, d), 8.00 (1H, d), 7.96 (1H, s), 7.86 (1H, dd), 5.36 (2H, s), 4.71 (1H, m), 3.63 (2H, m), 3.01 (4H, m), 2.2 (2H, m), 1.99 (2H, m), 1.64 (2H, m), 1.39 (2H, m), 0.89 (3H, t).

出典と根拠

ORDレコード
ord-b6926748903643e48749f99345296122
出典データセット
uspto-grants-2014_09
特許番号
US08846675B2

関連ノート

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