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Pyridine → 3,5-dimethyl-1-m-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | m-Tolylhydrazinium(1+) chloride | HCID 71562 | — |
| 反応物 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3,5-dimethyl-1-m-tolyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9878335 | — |
反応手順
Similar to Example 1, equimolar amounts of m-tolylhydrazine hydrochloride and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of a 50% pyridine in ethanol. The resulting oil was purified by flash chromatography to yield the named product as a solid (m.p. 46.5° C.–47.5° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087634B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-10ff9f3ebf424ef1bf07a369dc0fa429 |
| 出典メモ | uspto-grants-2006_08 |