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HRID 80723作成日：2026年10月25日
Hydrochloric Acid → 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine
https://huagongshe.com/reaction/80723
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Benzyloctahydropyrrolo[3,4-c]pyrrole | HCID 4454387 | — |
| 反応物 | 6-Chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine | HCID 59367714 | — |
| 溶媒 | 1-Pentanol | HCID 6276 | — |
| 生成物 | 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine | HCID 59406971 | — |
反応手順
A mixture of 3.00 g (10.9 mmol) of 6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine and 6.6 g (33 mmol) of 2-benzyloctahydropyrrolo[3,4-c]pyrrole in 20 mL of pentanol is heated at 150° C. for 2 days in a reactor. The medium is then poured into aqueous 1N hydrochloric acid solution. The aqueous phase is washed with ethyl acetate and then basified with sodium hydroxide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08846676B2 |
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| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-ae878798158d46dfae2ba814ab27e8f7 |
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| 出典メモ | uspto-grants-2014_09 |
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