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HRID 80736作成日：2026年10月23日
4-(1-Pyrrolidinyl)piperidine → 2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine
https://huagongshe.com/ja/reaction/80736
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-(1-Pyrrolidinyl)piperidine | HCID 78703 | — |
| 反応物 | 6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine | HCID 59406954 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine | HCID 59406955 | — |
反応手順
A mixture of 4.03 g (13.1 mmol) of 6-chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine and 4.4 g (29 mmol) of 4-pyrrolidin-1-ylpiperidine in 50 mL of ethanol is heated at 155° C. for 4 hours. After cooling, the solvent is evaporated off under reduced pressure and the residue is chromatographed on silica gel, eluting with a mixture of dichloromethane and methanol (93:7).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08846676B2 |
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| 出典データセット | uspto-grants-2014_09 |
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| ORD ID | ord-c2eb2d7b1f2042a3af4bc5b0db2ec5b6 |
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| 出典メモ | uspto-grants-2014_09 |
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