Dimethylformamide → N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-3-morpholin-4-yl-propionamide

反応式

[Br:1][CH2:2][CH2:3][C:4](=[O:5])[NH:6][c:7]1[s:8][c:9](-[c:13]2[n:14][c:15]([NH:19][c:20]3[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]3)[n:16][cH:17][cH:18]2)[c:10]([CH3:12])[n:11]1.[CH2:27]1[CH2:28][O:29][CH2:30][CH2:31][NH:32]1.[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[CH2:2]([CH2:3][C:4](=[O:5])[NH:6][c:7]1[s:8][c:9](-[c:13]2[n:14][c:15]([NH:19][c:20]3[cH:21][cH:22][c:23]([F:26])[cH:24][cH:25]3)[n:16][cH:17][cH:18]2)[c:10]([CH3:12])[n:11]1)[N:32]1[CH2:27][CH2:28][O:29][CH2:30][CH2:31]1

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 8083Morpholine

HCID 104781483-Bromo-N-{5-[2-(4-fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-propionamide

生成物 1

HCID 10366069N-{5-[2-(4-Fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-3-morpholin-4-yl-propionamide

出典と根拠

ORDレコード: ord-018c1b1ede174b21bc1cb2dcc4dacd82
出典データセット: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…