1-(2-(Dimethylamino)ethyl)piperazine → Dimethyl-(2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}ethyl)amine

HRID 80893

反応式

HRID 80893 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[CH3:18][N:19]([CH3:28])[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH3:18][N:19]([CH3:28])[CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][N:25]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)=[CH:4][N:3]=2)[CH2:24][CH2:23]1

参加物

3

反応物 2

HCID 27362291-(2-(Dimethylamino)ethyl)piperazineHCID 508526842-Chloro-5-[4-(trifluoromethyl)phenyl]pyridine

生成物 1

HCID 15951384Dimethyl-(2-{4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}ethyl)amine

実験手順

The title compound was prepared by a similar procedure to that described in Example 1, starting from 2-chloro-5-(4-trifluoromethylphenyl)pyridine and (2-dimethylaminoethyl)piperazine.

出典と根拠

ORDレコード
ord-5cf06e92fc62426790b6a9f42c0c31bc
出典データセット
uspto-grants-2014_09
特許番号
US08846677B2

関連ノート

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