(3-Acetamidophenyl)boronic acid → N-{3-[6-(4-Isopropylpiperazin-1-yl)-5-methylpyridin-3-yl]phenyl}acetamide

HRID 80919ノート

反応式

HRID 80919 の反応式
Br[C:2]1[CH:3]=[C:4]([CH3:17])[C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]([CH3:16])[CH3:15])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[C:18]([NH:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1)(=[O:20])[CH3:19]>>[CH:14]([N:11]1[CH2:12][CH2:13][N:8]([C:5]2[N:6]=[CH:7][C:2]([C:26]3[CH:27]=[C:22]([NH:21][C:18](=[O:20])[CH3:19])[CH:23]=[CH:24][CH:25]=3)=[CH:3][C:4]=2[CH3:17])[CH2:9][CH2:10]1)([CH3:16])[CH3:15]

参加物

3

反応物 2

HCID 157274(3-Acetamidophenyl)boronic acidHCID 671459611-(5-Bromo-3-methyl-pyridin-2-yl)-4-isopropyl-piperazine

生成物 1

HCID 15951459N-{3-[6-(4-Isopropylpiperazin-1-yl)-5-methylpyridin-3-yl]phenyl}acetamide

実験手順

The title compound was prepared by a similar procedure to that described in Example 68, starting from 1-(5-bromo-3-methyl-pyridin-2-yl)-4-isopropyl-piperazine and 3-acetylaminophenylboronic acid. 1H NMR (300 MHz, CDCl3) δ 8.35 (d, 1H), 7.77 (s, 1H), 7.58 (d, 1H), 7.46 (d, 2H), 7.35 (t, 1H), 3.32 (t, 4H), 2.92-2.75 (m, 5H), 2.30 (s, 3H), 2.19 (s, 3H), 1.14 (d, 6H).

出典と根拠

ORDレコード
ord-dbb795059eed4819aa1fb30aabb6b7a9
出典データセット
uspto-grants-2014_09
特許番号
US08846677B2

反応ノート

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