Ammonium Hydroxide → HCID 178461168、化合物
反応式
[NH4+].[OH-].S[C:4]1[N:5]=[C:6]([OH:14])[C:7]2[C@H:12]([CH3:13])[CH2:11][CH2:10][C:8]=2[N:9]=1>[Ni].O>[CH3:13][C@H:12]1[C:7]2[C:6]([OH:14])=[N:5][CH:4]=[N:9][C:8]=2[CH2:10][CH2:11]1参加物
5
実験手順
Raney Nickel (15 g) and NH4OH (20 mL) were added to a suspension of (R)-2-mercapto-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (12 g, 65.8 mmol) in distilled water (100 mL). The mixture was refluxed for 3 hours and then filtered. The filtrate was concentrated to afford (R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (9.89 g, 99%). MS (APCI+) [M+H]+ 151.
後処理
- temperatureThe mixture was refluxed for 3 hours
- filtrationfiltered
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-af4c6075e1864ed7a9e30c839d82b412
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846683B2
反応ノート
読み込み中…