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4-Chloroaniline → 4-chloro-N-(2-(diethylamino)ethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloroaniline | HCID 7812 | — |
| 反応物 | 2-Bromoethyldiethylammonium bromide | HCID 70607 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | Sodium Bicarbonate | HCID 516892 | — |
| 生成物 | 4-chloro-N-(2-(diethylamino)ethyl)aniline | HCID 224501 | — |
反応手順
4-Chloro-aniline (0.5 g, 3.9 mmol) was added to a solution of 2-bromo-N,N-diethylethylamine hydrobromide (1.12 g, 4.3 mmol) and N,N-diisopropylethylamine (2 mL, 11.7 mmol) in toluene (7.8 mL). The mixture was stirred at room temperature for 5 hours. The mixture was then diluted with EtOAc (30 mL) and saturated NaHCO3 (20 mL). The organic layer was washed with H2O (1×20 mL), dried (Na2SO4), filtered and concentrated to give 4-chloro-N-(2-(diethylamino)ethyl)benzenamine as an oil which was used without purification. MS (APCI+) [M+H]+ 227.3.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846683B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-fec6c0e3f3594fb2967b4d59a791e720 |
| 出典メモ | uspto-grants-2014_09 |