Potassium Carbonate → trans-2-(Benzylamino)-3,3-difluorocyclopentanol
反応式
C([O:4][C@@H:5]1[CH2:9][CH2:8][C:7]([F:11])([F:10])[C@H:6]1[NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH2:13]([NH:12][C@@H:6]1[C:7]([F:10])([F:11])[CH2:8][CH2:9][C@H:5]1[OH:4])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1参加物
4
実験手順
To a stirred solution of trans-2-(benzylamino)-3,3-difluorocyclopentyl acetate (100 mg, 0.37 mmol) in CH3OH (2 mL), K2CO3(52 mg, 0.37 mmol) was added at room temperature. The reaction mixture was stirred at room temperature for 1 hour and concentrated in vacuo. The residue was dissolved in CH2Cl2, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford trans-2-(benzylamino)-3,3-difluorocyclopentanol. MS ESI calc'd. for C12H15F2NO [M+H]+ 228. found 228.