関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethyl(methylene)ammounium iodide | HCID 2724133 | — |
| 反応物 | methyl 1H-indole-4-carboxylate | HCID 2733668 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-dimethylaminomethyl-1H-indole-4-carboxylic acid methyl ester hydroiodide | HCID 69518011 | — |
反応手順
Methyl indole-4-carboxylate (7.0 g, 40 mmol) and Eschenmoser's salt (N,N-dimethylmethyleneammonium iodide; 7.8 g, 42 mmol) are combined in 130 ml of acetic acid. After heating at 65° C. for 2 hours, the reaction mixture is concentrated in vacuo. The resulting solid is triturated with ethyl acetate, filtered and dried in vacuo to give 3-dimethylaminomethyl-1H-indole-4-carboxylic acid methyl ester hydroiodide in quantitative yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07087635B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-c7d2f163f53541348b1ec62b194c7f1c |
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| 出典メモ | uspto-grants-2006_08 |
|---|
