Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 81454

反応式

HRID 81454 の反応式
[CH3:1][N-:2]C.[NH2:4][C:5]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:6]=1[C:7](O)=[O:8].C(N)=O>O>[F:14][C:12]1[CH:13]=[C:5]2[C:6]([C:7](=[O:8])[NH:2][CH:1]=[N:4]2)=[CH:10][CH:11]=1

参加物

5

反応物 3

HCID 713FormamideHCID 182180DimethylazanideHCID 27249674-Fluoroanthranilic acid

生成物 1

HCID 1353984967-Fluoroquinazolin-4(3H)-one収率 78%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
180 °C

実験手順

A catalytic amount (1 ml) of N,N-dimethylamide was added to 2-amino-4-fluorobenzoic acid (50 g, 322 mmol) and formamide (77 ml, 1934 mmol), and the resulting solution was stirred. The solution was heated to 180° C. and stirred for 14 hours. The temperature of the solution was cooled to room temperature, and 300 ml of distilled water was added thereto. The resulting solid was stirred about 30 min, and filtered to obtain the title compound 41.3 g (yield: 78%).

後処理

  1. stirringstirred for 14 hours
  2. temperatureThe temperature of the solution was cooled to room temperature
  3. stirringThe resulting solid was stirred about 30 min
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-c6d31f2832c24e03bae54d8181808b82
出典データセット
uspto-grants-2014_09
特許番号
US08846699B2

関連ノート

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