Morpholine → 4-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 81484ノート

反応式

HRID 81484 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([S:8]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)(=[O:10])=[O:9])[CH:7]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 866319035-Chloro-2-(trifluoromethyl)benzene-1-sulfonyl chloride

生成物 1

HCID 686302274-(5-Chloro-2-trifluoromethyl-benzenesulfonyl)-morpholine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

5-Chloro-2-trifluoromethyl-benzenesulfonyl chloride (0.17 g, 0.62 mmol) is added to a solution of morphline (0.114 ml, 1.3 mol) in DCM (5 ml) and the resulting white suspension is stirred at room temperature overnight. The reaction mixture is diluted with DCM (5 ml), and washed with 0.1M HCl, dried (MgSO4) and concentrated in vacuo to yield the title compound. [M+H]+ 330.

後処理

  1. washwashed with 0.1M HCl
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-45708f4f8412433482efb34a2569e6cb
出典データセット
uspto-grants-2014_09
特許番号
US08846687B2

反応ノート

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