5-Bromopyridine-2-carboxylic acid → HCID 66665434、化合物

HRID 81541

反応式

HRID 81541 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH2:9][O:10][CH2:11][C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=2)([CH:14]([F:16])[F:15])[N:13]=1)([CH3:4])([CH3:3])[CH3:2].[Br:25][C:26]1[CH:27]=[CH:28][C:29]([C:32](O)=[O:33])=[N:30][CH:31]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH2:9][O:10][CH2:11][C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:32]([C:29]3[CH:28]=[CH:27][C:26]([Br:25])=[CH:31][N:30]=3)=[O:33])[CH:18]=2)([CH:14]([F:16])[F:15])[N:13]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 6085445-Bromopyridine-2-carboxylic acidHCID 66665306[5-(3-Amino-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

生成物 1

HCID 66665434HCID 66665434、化合物

実験手順

[5-(3-Amino-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester and 5-bromo-pyridine-2-carboxylic acid were coupled according the procedure described in example 51m). 1H-NMR (360 MHz, CDCl3): 9.92 (s, 1H, NH), 8.73 (s, 1H), 8.24 (d, 1H), 8.10 (d, 1H), 7.88 (m, 2H), 7.45 (m, 1H), 7.31 (m, 1H), 5.92 (t, 1H, CHF2), 4.84 (d, 1H), 4.65 (d, 1H), 4.31 (d, 1H), 3.96 (d, 1H), 1.52 (s, 9H); MS: 525 [(M+H)+].

出典と根拠

ORDレコード
ord-d9ba007f796344e9a317a794ce84e300
出典データセット
uspto-grants-2014_09
特許番号
US08846658B2

関連ノート

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