反応式
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.O1CCOC1[CH2:24][CH2:25][O:26][C:27]1[CH:28]=[C:29]([F:34])[C:30](F)=[N:31][CH:32]=1.CS(O[CH:40]1[CH2:43][N:42](C(OC(C)(C)C)=O)[CH2:41]1)(=O)=O>>[CH2:41]([N:42]1[CH2:24][CH:25]([O:26][C:27]2[CH:28]=[C:29]([F:34])[C:30]([O:18][C:15]3[CH:16]=[C:17]4[C:12](=[CH:13][CH:14]=3)[N:11]=[CH:10][N:9]=[C:8]4[NH:7][C:4]3[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=3)=[N:31][CH:32]=2)[CH2:43]1)[CH3:40]参加物
4
反応物 3
生成物 1
実験手順
Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol, 5-[2-(1,3-dioxolan-2-yl)ethoxy]-2,3-difluoropyridine and tert-butyl 3-[(methylsulfonyl)oxy]azetidine-1-carboxylate, and in the same manner as in Example 6-5) or according to a method similar to it or according to a combination thereof with an ordinary method, 6-({5-[(1-ethylazetidin-3-yl)oxy]-3-fluoropyridin-2-yl}oxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine was obtained.
出典と根拠
- ORDレコード
- ord-8da120759b19416fb1d57700d3f397f5
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846700B2
関連ノート
読み込み中…