2-{4-Amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide hydrochloride → 2-{4-Amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide
反応式
Cl.[NH2:2][C:3]1[C:4]2[C:5]3[C:6](=[N:18][N:19]([CH2:21][C:22]4[C:27]([Cl:28])=[C:26]([O:29][CH3:30])[C:25]([CH3:31])=[CH:24][N:23]=4)[N:20]=2)[CH:7]=[C:8]([CH2:13][C:14]([NH:16][CH3:17])=[O:15])[C:9]=3[CH2:10][S:11][N:12]=1>O>[NH2:2][C:3]1[C:4]2[C:5]3[C:6](=[N:18][N:19]([CH2:21][C:22]4[C:27]([Cl:28])=[C:26]([O:29][CH3:30])[C:25]([CH3:31])=[CH:24][N:23]=4)[N:20]=2)[CH:7]=[C:8]([CH2:13][C:14]([NH:16][CH3:17])=[O:15])[C:9]=3[CH2:10][S:11][N:12]=1参加物
3
反応物 1
生成物 1
試薬・触媒・溶媒 1
実験手順
Water (20 mL) was added to 2-{4-Amino-2-[(3-chloro-4-methoxy-5-methylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-8-yl}-N-methylacetamide monohydrochloride (which had been obtained by the same operations as those in the method described in the above Reference Example 2) (505 mg, 1.047 mmol), and the resulting mixture was then stirred at room temperature for 3 hours. Thereafter, a precipitate was collected by filtration, and was then air-dried at room temperature for 3 days, so as to obtain the above title compound as crystal P (426 mg, 0.883 mmol). Yield: 84%.
後処理
- customhad been obtained by the same operations as those in the method
- filtrationThereafter, a precipitate was collected by filtration
- customwas then air-dried at room temperature for 3 days
出典と根拠
- ORDレコード
- ord-e98c5e7f2c754beebfa8cbf23d4f9be7
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846703B2
反応ノート
読み込み中…