Water → Toluene-4-sulfonic acid 2-isopropyl-4-methoxy-phenyl ester

HRID 81780

反応式

HRID 81780 の反応式
[CH:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[OH:12])([CH3:3])[CH3:2].[C:13]1([CH3:23])[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=1.O>C(Cl)Cl>[CH:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[O:12][S:19]([C:16]1[CH:17]=[CH:18][C:13]([CH3:23])=[CH:14][CH:15]=1)(=[O:21])=[O:20])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 183649974-Methoxy-2-(propan-2-yl)phenol

生成物 1

HCID 44248852Toluene-4-sulfonic acid 2-isopropyl-4-methoxy-phenyl ester収率 74.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 2-isopropyl-4-methoxy-phenol (56.91 g, 342 mmol) triethylamine (57.3.0 ml, 411 mmol) in 750 ml CH2Cl2 was cooled to 0° C. p-Toluenesulfonyl chloride (68.54 g, 360 mmol) in 250 ml CH2Cl2 was added drop-wise at a rate that maintained the internal temperature <10° C. The mixture was allowed to warm to rt. After 16 h, H2O was added and the mixture was extracted with CH2Cl2. The combined organics were washed with brine, dried with Na2SO4, filtered and concentrated in vacuo to afford a crude solid. Recrystallization from hexanes afforded toluene-4-sulfonic acid 2-isopropyl-4-methoxy-phenyl ester (81.67 g, 74%) as white needles.

後処理

  1. additionwas added drop-wise at a rate that
  2. temperaturemaintained the internal temperature <10° C
  3. extractionthe mixture was extracted with CH2Cl2
  4. washThe combined organics were washed with brine
  5. dry with materialdried with Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. customto afford a crude solid
  9. customRecrystallization from hexanes

出典と根拠

ORDレコード
ord-42627a1fc2f541bcb7a85043a494c2fb
出典データセット
uspto-grants-2014_09
特許番号
US08846705B2

関連ノート

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