4-(Chloromethyl)-2-methyl-1,3-thiazole → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-methyl-thiazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

反応式

[Cl:36][CH2:37][c:38]1[n:39][c:40]([CH3:43])[s:41][cH:42]1.[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH2:9][CH2:10][C:11]3([C:12](=[O:24])[NH:13][C:14](=[O:23])[N:15]3[c:16]3[c:17]([CH3:22])[cH:18][cH:19][cH:20][cH:21]3)[CH2:25][CH2:26]2)[cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]1)([F:34])[F:35]>>[F:1][C:2]([c:3]1[cH:4][c:5]([C:6](=[O:7])[N:8]2[CH2:9][CH2:10][C:11]3([C:12](=[O:24])[N:13]([CH2:37][c:38]4[n:39][c:40]([CH3:43])[s:41][cH:42]4)[C:14](=[O:23])[N:15]3[c:16]3[c:17]([CH3:22])[cH:18][cH:19][cH:20][cH:21]3)[CH2:25][CH2:26]2)[cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]1)([F:34])[F:35]

参加物

反応物 2

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazole

HCID 101177418-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

生成物 1

HCID 101678118-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-methyl-thiazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

出典と根拠

ORDレコード: ord-19248c1615bc47809dd0aff5261999c9
出典データセット: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…