4-Acetoxy-3-phenyl-butyric Acid Methyl Ester → Dihydro-4-phenylfuran-2(3H)-one
反応式
COC(=O)C[CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:6][O:7][C:8](=[O:10])[CH3:9]>O1CCOCC1.S(=O)(=O)(O)O>[C:11]1([CH:5]2[CH2:6][O:7][C:8](=[O:10])[CH2:9]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1参加物
4
反応条件
- 温度
- 45 °C
実験手順
A solution of 4-acetoxy-3-phenyl-butyric acid methyl ester, (4.5 g, 19.2 mmol) in 1,4-dioxane (29 mL) and sulfuric acid (29 mL) is stirred at room temperature for one hour then heated at 45° C. for 18 h. Volatile solvents are evaporated and the residue is extracted with toluene. The combined organic extracts are extracted with water and brine, filtered, and concentrated to yield the title compound, 2.2 g (71%), as a colorless liquid.
後処理
- customVolatile solvents are evaporated
- extractionthe residue is extracted with toluene
- extractionThe combined organic extracts are extracted with water and brine
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-c72e25f5b65a41dcba6135476c5cb717
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087626B2
反応ノート
読み込み中…