関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Diethyl 2-oxosuccinate,sodium salt | HCID 57351814 | — |
| 反応物 | HCID 178418806 | HCID 178418806 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | ethyl 6-oxo-1,2-dihydropyrazolo[3,4-b]pyridine-4-carboxylate | HCID 178469358 | 28.4% |
反応手順
To a solution of 3-aminopyrazole (224 g, 2.7 mol) in water (1 L) were added a solution of diethyl oxalacetate sodium salt (567 g, 2.7 mol) in water (1.3 L) and then acetic acid in 4 portions (0.8 L). The reaction mixture was heated at 85° C. for 15 hours then cooled to room temperature and filtered. The precipitate was washed with water and then dried to afford the title compound as an orange solid (159 g, 28%). 1H NMR (250 MHz, DMSO): δ 1.35 (t, 3H), 4.36 (q, 2H), 6.69 (s, 1H), 8.16 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846712B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-e3eb65687a5b40aca63272abc8d1d7f7 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
