Dichloromethane → 2-(4-Chloro-phenyl)-4-(2-hydroxy-ethyl)-thiazole-5-carboxylic acid [3-methoxy-4-(4-triisopropylsilanyloxy-piperidin-1-yl)-phenyl]-amide

反応式

[CH3:1][O:2][c:3]1[cH:4][c:5]([NH2:26])[cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][CH:12]([O:15][Si:16]([CH:17]([CH3:18])[CH3:19])([CH:20]([CH3:21])[CH3:22])[CH:23]([CH3:24])[CH3:25])[CH2:13][CH2:14]1.[CH3:27][Al:28]([CH3:29])[CH3:30].[Cl:31][c:32]1[cH:33][cH:34][c:35](-[c:38]2[s:39][c:40]3[c:41]([n:42]2)[CH2:43][CH2:44][O:45][C:46]3=[O:47])[cH:36][cH:37]1.[Cl:48][CH2:49][Cl:50]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([NH:26][C:46]([c:40]2[s:39][c:38](-[c:35]3[cH:34][cH:33][c:32]([Cl:31])[cH:37][cH:36]3)[n:42][c:41]2[CH2:43][CH2:44][OH:45])=[O:47])[cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][CH:12]([O:15][Si:16]([CH:17]([CH3:18])[CH3:19])([CH:20]([CH3:21])[CH3:22])[CH:23]([CH3:24])[CH3:25])[CH2:13][CH2:14]1